Arizona Biosciences News

UA cancer researcher featured in Nature

Tags: cancer, dna, ua

Summary:

Laurence Hurley, D.Sc., globally renowned leader in the development of cancer therapeutic agents, was featured recently in "Beyond the Double Helix," a retrospective focusing on how scientists' understanding of the DNA molecule has changed since the publication of Watson and Cricks' seminal paper 50 year ago.

Full Story:

Laurence Hurley, D.Sc., globally renowned leader in the development of cancer therapeutic agents, was featured recently in "Beyond the Double Helix," a retrospective focusing on how scientists' understanding of the DNA molecule has changed since the publication of Watson and Cricks' seminal paper 50 year ago. The article, published in the January 23, 2003, edition of Nature, profiles research in a number of areas that bolsters the increasingly popular notion of DNA not as a static molecule, but rather a dynamic structure with multiple morphologies.

Dr. Hurley suspects that one such morphology, dubbed "G-quadruplex," may play an important role in fending off gene-activating proteins, thereby helping to prevent certain cancer causing genes, such as c-MYC, from being switched on. He is currently researching anti-cancer drugs that will function on this principle.

Hurley joined the University of Arizona College of Pharmacy in 1999, and is the first researcher to hold the $2-million Howard J. Schaeffer, Ph.D., Endowed Chair in Pharmaceutical Sciences.


For more information:

Hurley Research Group home page