New Alzheimer genes fail for risk prediction

May 12, 2010

By hammersmith

[Source: Med Page Today] -The largest genome-wide association study in Alzheimer’s disease to date has identified two new genetic variants and confirmed two others, but research leaders conceded that they would have little predictive value in the clinic.


Polymorphisms near the BIN1 and EXOC3L2 genes were more common in people with Alzheimer’s disease, with odds ratios in a replication sample of 1.17 (95% CI 1.03 to 1.33) and 1.25 (95% CI 1.05 to 1.51), respectively, according to Monique Breteler, MD, PhD, of University Medical Center in Rotterdam, the Netherlands, and colleagues.

For more information: New Alzheimer Genes Fail for Risk Prediction