ID genetic markers that could improve effectiveness of diabetes therapies

July 3, 2009

By Flinn Foundation

[Source:] – Scientists have identified five genetic biomarkers that predict how well a type 2 patient will respond to the drug Actos. Their work could be the first step toward a system that would allow doctors to predetermine which drugs will best help each person with diabetes. 

Actos, manufactured by Takeda Pharmaceutical Company Ltd., is a thiazolidinedione, a drug that improves insulin sensitivity while decreasing the quantity of glucose and glycated hemoglobin (hemoglobin that has glucose and other sugars bound to it) in the bloodstream.

The scientists, from the University of Southern California’s Keck School of Medicine and the Translational Genomics Research Institute in Phoenix, found the five biomarkers as they were investigating why up to 40 percent of patients treated with Actos fail to respond with improvement in their insulin sensitivity.

For more information: ID Genetic Markers That Could Improve Effectiveness of Diabetes Therapies