Bioscience

Researchers identify proteins that might contribute to memory loss and Alzheimer

January 15, 2010

By Flinn Foundation

[Source: TGen] – A scientific group led by the Translational Genomics Research Institute (TGen) have identified three kinases, or proteins, that dismantle connections within brain cells, which may lead to memory loss associated with Alzheimer’s disease.

These findings, the results of a multi-year TGen study, are published in this month’s edition of BMC Genomics in a paper titled: High-content siRNA screening of the kinome identifies kinases involved in Alzheimer’s disease-related tau hyperphosphorylation.

The three kinases were found to cause a malfunction in tau, a protein critical to the formation of the microtubule bridges within brain cells, or neurons. These bridges support the synaptic connections that, like computer circuits, allow neurons to communicate with each other.

For more information: Researchers identify proteins that might contribute to memory loss and Alzheimer’s disease