Bioscience

TGen finds protein inhibitor revives chemotherapy for ovarian patients

July 6, 2010

By Flinn Foundation

[Source: Bio-Medicine] – Investigators at the Translational Genomics Research Institute (TGen) have discovered a way that may help ovarian cancer patients who no longer respond to conventional chemotherapy.

A scientific paper that will be published in the September issue of the journal Gynecologic Oncology describes how the inhibition of a protein, CHEK1, may be an effective element to incorporate into therapies for women with ovarian cancer.

The research led by TGen’s Dr. David Azorsa, a Senior Investigator, and Dr. Shilpi Arora, a Staff Scientist, found that inhibiting CHEK1 by a small molecule known as PD 407824, enabled ovarian cancer cells to be attacked again by cisplatin, a widely used platinum-based chemotherapy drug for women with ovarian cancer.

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