Bioscience

Lung cancer oncogene holds key to turning off cancer stem cells

September 8, 2009

By Flinn Foundation

[Source: ScienceDaily] – Scientists at the Mayo Clinic campus in Florida have found that the lung cancer oncogene PKCiota is necessary for the proliferation of lung cancer stem cells. These stem cells are rare and powerful master cells that manufacture the other cells that make up lung tumors and are resistant to chemotherapy treatment.

Their study, published in the Oct. 1 issue of Cancer Research, also shows that an agent, aurothiomalate, being tested at Mayo Clinic in a phase I clinical trial substantially inhibits growth of these cancer stem cells.

For more information: Lung Cancer Oncogene Holds Key To Turning Off Cancer Stem Cells